Management of Hypoparathyroidism: Summary Statement and Guidelines
Report #1 from the First International Conference on “The Diagnosis, Management and Treatment of Hypoparathyroidism” held in Florence, Italy May 7–9, 2015. (Liz Glenister attended for Hypopara UK)
Maria Luisa Brandi1 , John P. Bilezikian2 , Dolores Shoback3 , Roger Bouillon4 , Bart Clarke5 , Rajesh V. Thakker6 , Aliya Khan7 , and John T. Potts Jr8 1 Department of Surgery and Translational Medicine, University of Florence, Italy; 2 Columbia University College of Physicians & Surgeons, NY, NY USA; 3 Endocrine Research Unit, San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco USA; 4 Clinic and laboratory of experimental endocrinology, Gasthuisberg, KU Leuven, 3000 Leuven, Belgium; 5 Mayo Clinic Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, MN, USA 55905; 6 Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, OCDEM, Churchill Hospital, Oxford, OX3 7LJ, UK.; 7 McMaster University Calcium Disorders Clinic, Hamilton, Canada; 8 Massachusetts General Hospital, Boston, MA, United States
Objective: Hypoparathyroidism is a rare disorder characterized by hypocalcemia and absent or deficient parathyroid hormone. This report presents a summary of current information about epidemiology, presentation, diagnosis, clinical features and management and proposes guidelines to help clinicians diagnose, evaluate and manage this disorder.
Participants: Participants in the First International Conference on the Management of Hypoparathyroidism represented a worldwide constituency with acknowledged interest and expertise in key basic, translational and clinical aspects of hypoparathyroidism. Three Workshop Panels were constituted to address questions for presentation and discussion at the Conference held in Florence, Italy, May 7–9, 2015. At that time, a series of presentations were made followed by in-depth discussions in an open forum. Each Workshop Panel also met in closed sessions to formulate the three evidence-based reports that accompany this summary statement. An Expert Panel then considered this information, developed summaries, guidelines, and a research agenda that constitutes this summary statement.
Evidence: Preceding the conference, each Workshop Panel conducted an extensive literature search as noted in the individual manuscripts accompanying this report. All presentations were based upon the best peer-reviewed information taking into account the historical and current literature.
Consensus Process: This report represents the Expert Panel’s synthesis of the conference material placed in a context designed to be relevant to clinicians and those engaged in cutting-edge studies of hypoparathyroidism.
Conclusions: This document provides not only a summary of our current knowledge but also places recent advances in its management into a context that should enhance future advances in our understanding of hypoparathyroidism.
Click to read full paper http://press.endocrine.org/doi/pdf/10.1210/jc.2015-3907