The Research Collection

Key papers on hypoparathyroidism, hyperparathyroidism and surgery.


Prolonged spontaneous normocalcaemia in pseudohypoparathyroidism from resorption of soft tissue calcium deposits: a cautionary tale. Carter EE, Kline G, BMJ Case Rep 2014 Jan 30;2014. pii: bcr2013202729. doi: 10.1136/bcr-2013-202729.




Predictors of Hypocalcemia after Thyroidectomy: Results from the Nationwide Inpatient Sample RL. BaldassarreDC. ChangKT. BrumundM.Bouvet. IRSN Surg. 2012;2012:838614


Influence of experience on performance of individual surgeons in thyroid surgery: prospective cross sectional multicentre study
Duclos et al, BMJ 2012:344

Mini-review: new therapeutic options in hypoparathyroidism.
Cusamo,NERubin MRSliney J JrBilezikian JP. Endocrine 2012 Jun;41(3):410-4. Epub 2012 Feb 7.



Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
JP Bilezikian, A Khan, JT Potts, ML Brandi, BL Clarke, D.Shoback, H.Juppner, P. D'Amour, J.Fox, L. Rejnmark, L.Mosekilde, MR. Rubin, D.Dempster, R.Gafni, MT Collins, J.Sliney, J.Sanders.Journal of Bone and Mineral Research,Volume 26Issue 10pages 2317–2337October 2011. 

Synthetic human parathyroid hormone 1-34 replacement therapy : A randomised crossover trial comparing pump versus injection in the treatment of chronic hypoparathyroidism.
K.Winer et al J,Clim Edocri ol. Metab 2011 Nov 16. [Epub ahead of print]

The effect of adding PTH(1-84) to conventional treatment of hypoparathyroidism: a randomized, placebo-controlled study. Sikjaer, Reinmark, Rolighed, Heinkendorff, Mosekiilde, Hypoparathyroidism Study Group;  J Bone Miner Res2011 Oct;26(10):2358-70. doi: 10.1002/jbmr.470.



Hypocalcaemia after thyroidectomy: the need for improved defenitions
Jessie Wu & Barney Harrison WJES Jan-April 2010;2(1):17-20

Diagnosis and management of vitamin D deficiency
Pearce and Cheetham BMJ Jan 2010;340;b5664

Outcome of protracted hypoparathyroidism after total thyroidectomy.Sitges-Serra ARuiz SGirvent MManjón HDueñas JPSancho JJ. 2010 Nov;97(11):1687-95.

Long-term treatment of 12 children with chronic hypoparathyroidism: a randomized trial comparing synthetic human parathyroid hormone 1–34 versus calcitriol and calcium. Winer KKSinaii NReynolds JPeterson DDowdy KCutler GB Jr. J Clin Endocrinol Metab. 2010;95:26808.

Parathyroid Disorders and Diseases Altering Calcium Metabolism. 
Thakker R (2010) In: Warrell, D.A., Cox, T.M. and Firth, J.D. (Eds.) Oxford textbook of medicine. Volume 2, 5th edn. Oxford, UK: Oxford University Press. Chapter 13.6

Therapy of hypoparathyroidism with intact parathyroid hormone.
Rubin MRSliney J JrMcMahon DJSilverberg SJBilezikian JP. Osteoporosis Int. 2010 Nov;21(11):1927-34. Epub 2010 Jan 22.



A Practical Approach to Hypocalcaemia in Children
Nick Shaw in Allgrove J, Shaw NJ (eds): Calcium and Bone Disorders in Children and Adolescents.Endocr Dev. Basel, Karger, 2009, vol 16, pp 73–92

Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Third International Workshop. 
Bilezikian JPKhan APotts JT Jr.J Clin Endocrinol Metab. 2009;94:3359.

Anti-Parathyroid and Anti-Calcium Sensing Receptor Antibodies in Autoimmune Hypoparathyroidism
Brown, E. Endocrinology and Metabolism Clinics. 2009;38(2).



Diagnosis & Management of Hypocalcaemia: Clinical Review
Cooper and Gittoes  BMJ  2008;336:1298-1302 (7 June)2008

Unrecognised Severe Hypovitaminosis D
Sievenpiper, McIntrye, Verrill, Quinton, Pearce BMJ  2008;336:1371-1374 (14 June)

Hypoparathyroidism: Is It Time for Replacement Therapy?
Horwitz and Stewart (93 (9): 3307 JECM 2008) Click PDF download

Hypoparathyroidism : Clinical Review
Shoback, D NEJM Vol 359:391-403 July 2008

Vitamin D status in postmenopausal women living at higher latitudes in the UK 
Macdonald, Macvroeid, Barr,Black , Fraser, Reid  (Vol 42:5, 996-1003, May 2008 Bone)

DiGeorge Syndrome presenting as late onset hypocalcaemia in adulthood
Johnston, Donnelly, Morrison and Hunter Ulster Med J 2008; 77 (3) 201-202

Effects of once versus twice -daily PTH 1-34 therapy in children with HPTH
Winer, Sinaii, Peterson, Sainz, Cutler  JCEM 2008 Sep;93(9):3389-952008

Dynamic and structural properties of the skeleton in hypoparathyroidism.
J Bone Miner Res. 2008;23(12):2018-34.Rubin MR, Dempster DW, Zhou H, Shane E, Nickolas T, Sliney J,Silverberg SJ, Bilezikian JP.  

Hypoparathyroidism after total thyroidectomy: A prospective study
Asari RKoperek OKaczirek K, et al. 
Arch Surg.2008;143:1327.

Best practice in primary care pathology: review 11.
Smellie, W.S., Vanderpump, M.P., Fraser, W.D. et al. (2008
Journal of Clinical Pathology 61(4), 410-418.



Vitamin D Deficiency: Clinical Review
Holick, MF  NEJM Volume 357:266-281 July 2007

Cyclical changes in calcium metabolism across the menstrual cycle in women with premenstrual dysphoric disorder
Thys-Jacobs, McMahon, Bilezikian JCEM 2007

Hypocalcemic tetany in the newborn as a manifestation of unrecognized maternal primary hyperparathyroidism. 
Pieringer H, Hatzl-Griesenhofer M, Shebl O, et al.  Wien Klin Wochenschr. 2007;119:129-131

The impact of single parathyroid gland autotransplantation during thyroid surgery on postoperative hypoparathyroidism: a multicenter study. Transplant Proc.Testini M, Rosato L, Avenia N, et al.  2007;39:225-230.



Withdrawal of alfacalcidol supplements following thyroidectomy: baseline plasma PTH predicts successful outcome
Morris, M & Perros, P  Presented at European Congress of Endocrinology, Glasgow 2006 (Endocrine Abstracts 11: P919 2006)



A comparison of corrected serum calcium levels to ionized calcium levels among critically ill surgical patients.
Byrnes MC, Huynh K, Helmer SD, et al.  Am J Surg. 2005;189:310-314.

Magnesium deficiency in critical illness
Tong GMRude RKJ Intensive Care Med. 2005;20:317.



Severe hypocalcaemia after being given intravenous bisphosphonate
Peter R, Mishra V, Fraser WD BMJ, Feb 2004 328(7435):335-336

Minimally invasive parathyroid surgery
Udelsman R, Donovan PI.  World J Surg. 2004;28:1224-1226



The impact of surgical technique on postoperative hypoparathyroidism in bilateral thyroid surgery: a multivariate analysis of 5846 consecutive patients
Thomusch OMachens ASekulla C, et al.  Surgery. 2003;133:18095.

Long-term treatment of hypoparathyroidism: A randomized controlled study comparing parathyroid hormone versus calcitriol and calcium.
Winer KK, Ko CW, Reynolds JC, et al. J Clin Endocrinol Metab. 2003;88:4214-4220.

Prevention, evaluation, and management of complications following thyroidectomy for thyroid carcinoma. Zarnegar RBrunaud LClark OHEndocrinol Metab Clin North Am. 2003;32:483502.



Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D
Arlt, Fremerey, Callies, Reincke, Schneider, Timmermann,  B Allolio. European Journal of Endocrinology 146: 215 - 222, Feb 2002 



Hypocalcaemic Disorders
Thakker, RV, Medecine Vol 29 pp57-59, 2001.

Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. Neer RMArnaud CDZanchetta JR, et al. N Engl J Med. 2001;344:143441.



Genetic ablation of parathyroid glands reveals another source of parathyroid hormoneGunther TChen ZFKim J, et al.Nature.2000;406:199203.



Oestrogen and calcium homeostasis in women with hypoparathyroidism
Oestrogen status can affect the requirement for vitamin D in women with hypoparathyroidism
Janet McIlroy, Frances Dryburgh,John Hinnie, Dargie, Al-Rawi, Department of Clinical Biochemistry, Glasgow Royal Infirmary, BMJ 1999;319:1252-1253



Bilezikian JPThakker RV
Current Opinion in Endocrinology. 1998;4:42732.


Postoperative tetany in patients with Graves' disease: a risk factor analysis.
Yamashita H, Noguchi S, Tahara K, et al.  Clin Endocrinol (Oxf). 1997;47:71-77



Parathyroid autotransplantation during thyroidectomy. Results of long-term follow-up. Olson J, DeBenedetti M, Baumann D, et al. Ann Surg. 1996;223:472-478.


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