The Research Collection

Key papers on hypoparathyroidism, hyperparathyroidism and surgery.


Understanding the burden of illness associated with hypoparathyroidism reported among patients in the Paradox study.Hadker, Eden, Sanders, Lagast, Clarke Endocrine Practice Vol20 No7 July 2014 

Prolonged spontaneous normocalcaemia in pseudohypoparathyroidism from resorption of soft tissue calcium deposits: a cautionary tale. Carter EE, Kline G, BMJ Case Rep 2014 Jan 30;2014. pii: bcr2013202729. doi: 10.1136/bcr-2013-202729.




Predictors of Hypocalcemia after Thyroidectomy: Results from the Nationwide Inpatient Sample RL. BaldassarreDC. ChangKT. BrumundM.Bouvet. IRSN Surg. 2012;2012:838614


Influence of experience on performance of individual surgeons in thyroid surgery: prospective cross sectional multicentre study
Duclos et al, BMJ 2012:344

Mini-review: new therapeutic options in hypoparathyroidism.
Cusamo,NERubin MRSliney J JrBilezikian JP. Endocrine 2012 Jun;41(3):410-4. Epub 2012 Feb 7.



Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
JP Bilezikian, A Khan, JT Potts, ML Brandi, BL Clarke, D.Shoback, H.Juppner, P. D'Amour, J.Fox, L. Rejnmark, L.Mosekilde, MR. Rubin, D.Dempster, R.Gafni, MT Collins, J.Sliney, J.Sanders.Journal of Bone and Mineral Research,Volume 26Issue 10pages 2317–2337October 2011. 

Synthetic human parathyroid hormone 1-34 replacement therapy : A randomised crossover trial comparing pump versus injection in the treatment of chronic hypoparathyroidism.
K.Winer et al J,Clim Edocri ol. Metab 2011 Nov 16. [Epub ahead of print]

The effect of adding PTH(1-84) to conventional treatment of hypoparathyroidism: a randomized, placebo-controlled study. Sikjaer, Reinmark, Rolighed, Heinkendorff, Mosekiilde, Hypoparathyroidism Study Group;  J Bone Miner Res2011 Oct;26(10):2358-70. doi: 10.1002/jbmr.470.



Hypocalcaemia after thyroidectomy: the need for improved defenitions
Jessie Wu & Barney Harrison WJES Jan-April 2010;2(1):17-20

Diagnosis and management of vitamin D deficiency
Pearce and Cheetham BMJ Jan 2010;340;b5664

Outcome of protracted hypoparathyroidism after total thyroidectomy.Sitges-Serra ARuiz SGirvent MManjón HDueñas JPSancho JJ. 2010 Nov;97(11):1687-95.

Long-term treatment of 12 children with chronic hypoparathyroidism: a randomized trial comparing synthetic human parathyroid hormone 1–34 versus calcitriol and calcium. Winer KKSinaii NReynolds JPeterson DDowdy KCutler GB Jr. J Clin Endocrinol Metab. 2010;95:26808.

Parathyroid Disorders and Diseases Altering Calcium Metabolism. 
Thakker R (2010) In: Warrell, D.A., Cox, T.M. and Firth, J.D. (Eds.) Oxford textbook of medicine. Volume 2, 5th edn. Oxford, UK: Oxford University Press. Chapter 13.6

Therapy of hypoparathyroidism with intact parathyroid hormone.
Rubin MRSliney J JrMcMahon DJSilverberg SJBilezikian JP. Osteoporosis Int. 2010 Nov;21(11):1927-34. Epub 2010 Jan 22.



A Practical Approach to Hypocalcaemia in Children
Nick Shaw in Allgrove J, Shaw NJ (eds): Calcium and Bone Disorders in Children and Adolescents.Endocr Dev. Basel, Karger, 2009, vol 16, pp 73–92

Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Third International Workshop. 
Bilezikian JPKhan APotts JT Jr.J Clin Endocrinol Metab. 2009;94:3359.

Anti-Parathyroid and Anti-Calcium Sensing Receptor Antibodies in Autoimmune Hypoparathyroidism
Brown, E. Endocrinology and Metabolism Clinics. 2009;38(2).



Diagnosis & Management of Hypocalcaemia: Clinical Review
Cooper and Gittoes  BMJ  2008;336:1298-1302 (7 June)2008

Unrecognised Severe Hypovitaminosis D
Sievenpiper, McIntrye, Verrill, Quinton, Pearce BMJ  2008;336:1371-1374 (14 June)

Hypoparathyroidism: Is It Time for Replacement Therapy?
Horwitz and Stewart (93 (9): 3307 JECM 2008) Click PDF download

Hypoparathyroidism : Clinical Review
Shoback, D NEJM Vol 359:391-403 July 2008

Vitamin D status in postmenopausal women living at higher latitudes in the UK 
Macdonald, Macvroeid, Barr,Black , Fraser, Reid  (Vol 42:5, 996-1003, May 2008 Bone)

DiGeorge Syndrome presenting as late onset hypocalcaemia in adulthood
Johnston, Donnelly, Morrison and Hunter Ulster Med J 2008; 77 (3) 201-202

Effects of once versus twice -daily PTH 1-34 therapy in children with HPTH
Winer, Sinaii, Peterson, Sainz, Cutler  JCEM 2008 Sep;93(9):3389-952008

Dynamic and structural properties of the skeleton in hypoparathyroidism.
J Bone Miner Res. 2008;23(12):2018-34.Rubin MR, Dempster DW, Zhou H, Shane E, Nickolas T, Sliney J,Silverberg SJ, Bilezikian JP.  

Hypoparathyroidism after total thyroidectomy: A prospective study
Asari RKoperek OKaczirek K, et al. 
Arch Surg.2008;143:1327.

Best practice in primary care pathology: review 11.
Smellie, W.S., Vanderpump, M.P., Fraser, W.D. et al. (2008
Journal of Clinical Pathology 61(4), 410-418.



Vitamin D Deficiency: Clinical Review
Holick, MF  NEJM Volume 357:266-281 July 2007

Cyclical changes in calcium metabolism across the menstrual cycle in women with premenstrual dysphoric disorder
Thys-Jacobs, McMahon, Bilezikian JCEM 2007

Hypocalcemic tetany in the newborn as a manifestation of unrecognized maternal primary hyperparathyroidism. 
Pieringer H, Hatzl-Griesenhofer M, Shebl O, et al.  Wien Klin Wochenschr. 2007;119:129-131

The impact of single parathyroid gland autotransplantation during thyroid surgery on postoperative hypoparathyroidism: a multicenter study. Transplant Proc.Testini M, Rosato L, Avenia N, et al.  2007;39:225-230.



Withdrawal of alfacalcidol supplements following thyroidectomy: baseline plasma PTH predicts successful outcome
Morris, M & Perros, P  Presented at European Congress of Endocrinology, Glasgow 2006 (Endocrine Abstracts 11: P919 2006)



A comparison of corrected serum calcium levels to ionized calcium levels among critically ill surgical patients.
Byrnes MC, Huynh K, Helmer SD, et al.  Am J Surg. 2005;189:310-314.

Magnesium deficiency in critical illness
Tong GMRude RKJ Intensive Care Med. 2005;20:317.



Severe hypocalcaemia after being given intravenous bisphosphonate
Peter R, Mishra V, Fraser WD BMJ, Feb 2004 328(7435):335-336

Minimally invasive parathyroid surgery
Udelsman R, Donovan PI.  World J Surg. 2004;28:1224-1226



The impact of surgical technique on postoperative hypoparathyroidism in bilateral thyroid surgery: a multivariate analysis of 5846 consecutive patients
Thomusch OMachens ASekulla C, et al.  Surgery. 2003;133:18095.

Long-term treatment of hypoparathyroidism: A randomized controlled study comparing parathyroid hormone versus calcitriol and calcium.
Winer KK, Ko CW, Reynolds JC, et al. J Clin Endocrinol Metab. 2003;88:4214-4220.

Prevention, evaluation, and management of complications following thyroidectomy for thyroid carcinoma. Zarnegar RBrunaud LClark OHEndocrinol Metab Clin North Am. 2003;32:483502.



Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D
Arlt, Fremerey, Callies, Reincke, Schneider, Timmermann,  B Allolio. European Journal of Endocrinology 146: 215 - 222, Feb 2002 



Hypocalcaemic Disorders
Thakker, RV, Medecine Vol 29 pp57-59, 2001.

Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. Neer RMArnaud CDZanchetta JR, et al. N Engl J Med. 2001;344:143441.



Genetic ablation of parathyroid glands reveals another source of parathyroid hormoneGunther TChen ZFKim J, et al.Nature.2000;406:199203.



Oestrogen and calcium homeostasis in women with hypoparathyroidism
Oestrogen status can affect the requirement for vitamin D in women with hypoparathyroidism
Janet McIlroy, Frances Dryburgh,John Hinnie, Dargie, Al-Rawi, Department of Clinical Biochemistry, Glasgow Royal Infirmary, BMJ 1999;319:1252-1253



Bilezikian JPThakker RV
Current Opinion in Endocrinology. 1998;4:42732.


Postoperative tetany in patients with Graves' disease: a risk factor analysis.
Yamashita H, Noguchi S, Tahara K, et al.  Clin Endocrinol (Oxf). 1997;47:71-77



Parathyroid autotransplantation during thyroidectomy. Results of long-term follow-up. Olson J, DeBenedetti M, Baumann D, et al. Ann Surg. 1996;223:472-478.


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